Why Vitamin D is essential for a better Quality of Life

I have been a strong advocate for vitamin D within the last decade. I have regularly recommended this immunoregulatory hormone to my friends and family lso supplemented it myself. In addition, I have spent weeks and months working on so-called causal-loop diagrams to understand the metabolic pathways of vitamin D. I have also studied the effects of vitamin D on the immune system (see Figure 1).

Figure 1. Causal loop diagram of the impact of vitamin D3 on the immune system. It’s a bit nerdy, so you don’t need to try to comprehend it.

My knowledge only became relevant during the COVID plandemic. I quickly realised something was wrong because not a single scientist or politician was advising people to go out in the sun or supplement. Instead, the slogans were "stay indoors and don't go outside!".

So I decided to write down my knowledge and publish about vitamin D - especially about the relevance of vitamin K2, which should be taken together with vitamin D. I explain this in my publication "Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate" as follows:

Oral supplementation of D3 is the easiest means to prevent deficiencies. A frequent argument against supplementation of vitamin D3 is that an increased intake could lead to a vitamin D toxicity, also called hypervitaminosis D (Orme et al., 2016). This again can cause hypercalcemia, which is the buildup of calcium in the blood leading to vascular calcification, osteoporosis, and kidney stones. However, it has been reported that the reason for hypercalcemia rather lays in a vitamin K2 deficiency (Flore et al., 2013, Vermeer and Theuwissen, 2011), as K2 activates the bone gamma-carboxyglutamic acid-containing protein (osteocalcin) through carboxylation. Activated osteocalcin deposits calcium in the bones, whereas non-activated osteocalcin inhibits calcium absorption by the bones. As the osteocalcin synthesis rate is increased by higher 25(OH)D serum levels, K2 is required as a natural antagonist (Yasui et al., 2006, Dofferhoff et al., 2020).

Team Science vs Team Science ™

The fact that vitamin D is crucial for a functioning immune system is well-founded knowledge. Nevertheless, I was temporarily and ultimately permanently banned from Twitter for tweets that pointed this out. Twitter’s justification: medical misinformation. In my opinion, the WHO is the main source of all ills in this case. I consider its statement on vitamin D that a blood serum level of 20ng/mL is sufficient also misleading and potentially dangerous.

The threshold of Vitamin D deficiency is a continuous subject of discussion. Whereas the European Food Safety Authority recommends a minimum serum level of 25(OH)D of 25 nmol/L (i.e. 10 ng/mL) (EFSA, 2016), many scholars consider this value way too conservative. A study that was conducted in Kenya on healthy black males showed that 25(OH)D levels <30 ng/mL were associated with a significant rise in physiological markers such as parathyroid hormone (PTH) (Kagotho et al., 2018).

Figure 2 below shows the “Hazard Ratio” concerning different blood serum levels. For example, people with a blood serum level of 30ng/mL and below are at significant risk of getting sick in the short and long term. This does not only refer to common cold viruses but also decreases the likelihood of getting cancer like this study states:

The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.

Figure 2. 50ng/mL is needed for proper immune system function.

So I can only recommend that you make sure you have a healthy vitamin D blood serum level. I myself (male, mid-30s, 80kg, 16% body fat) supplement with 7000 IU vitamin D3 and 200 mcg vitamin K2-MK7 daily and have a level of 70 ng/mL. GrassrootHealth offers a great vitamin D calculator that I can only recommend.

Being healthy means quality of life.

In addition to a good diet and regular exercise, vitamin D is an important and favourable building block for ensuring this quality of life. Try to get sun every day and supplement in the dark and cold months. Your body will thank you.

Cheers,

Simon :)