Vitamin D is an immunoregulating hormone. Having 25(OH)D3 bloodserum values of 50-100ng/mL highly reduces the risk of being affected by almost all existing diseases, including allergies, cancer, and depression. However, there are two significant interrelated problems regarding Vitamin D.
Anything which costs you money is someone else with their hand in your pocket, taking your hard earned money out of it. If you want to beat Covid - kill the Coronaviruses before they ever get to be Covid this way: One heaped teaspoon of salt in a mug of warm water. Cup a hand. Sniff or Snort the lot up your nose, spitting out anything which comes down into your mouth. Burning sensation, you have a virus, so do this treatment 3 times a day (or more often) until the soreness goes away for good - blow your nose out in toilet paper and flush away washing your hands afterwards. RN has been doing his simple cure for over 29 years and he never gets Covid or a cold, me too - do the math - Vaccines released under 2 years ago vs 29 years.
When you do the salt water sniffle and it feels like you are flushing your head with water, you are OK - simple.
If you don't get Covid, because you can't, because you killed the Coronavirus, then you don't need to fork out money on cures which don't work, because if they did lots of people would be saying this works. but do you hear anyone taking Vitamin D saying it does anything. No!!
The reality is that you take Vitamin D by mouth. The pill goes down into your stomach, where it is ejected as surplus to requirements in your piss or shit - you need it to pass through the blood brain barrier, but it does not, which is why you smell it in your piss or shit.
So what makes an expert these days - people who were not experts 18 months ago - they can't forecast the future, because it has not happened yet and the past of these vaccines is only 18 months or so - disaster they have proved themselves to be, unless the purpose behind them was never Covid, but extermination and the ones who survive 50% of the way towards being Androids. Part human part machine.
Nice compilation - nutritionist 2 cents - vitamin D will not improve if the person is low in magnesium or the transport Vitamin D Binding protein/ GcMAF. Study design needs to include assessment of protein adequacy in the participant's diet and their ability to absorb magnesium. Poor gut absorption of magnesium may be an underlying factor in low vitamin D levels (and/or glyphosate interference with mineral and/or CYP enzymes).
*addition, and some pathogens or conditions include over-conversion to the active 1, 25 D so a few patients may be harmed by high dose supplements while still showing low levels of 25 D -- it is being converted to 1, 25 D.
Thank you for the explanation. You often here comments like “the studies are flawed” or “it’s bad science” but we rarely get an explanation as to why. Your insight is a treasure.
I am writing an essay on immunoprotective strategies for the elderly at the moment and had no concise reference for lay readers to understand the problems inherent with most of the vitD literature. Very happy to have found this today and even happier to see the link to Robin’s article. Robin is a citizen-scientist hero in my book—doggedly persistent to raise public health awareness on this issue art C19 prevention. If there were medals for citizen-scientists, I would nominate Robin. Also, I would like to point ppl to the work of Sunil Wimilawansa, MD on ResearchGate. Dr. Wimilawansa provides guidance for the safe use of calcifediol, over the counter via d.velop —in the context of new onset respiratory illness. This will rapidly raise D levels for those who have not previously supplemented. Very helpful in the winter for the elderly.
Of interest, have you reviewed any of the studies that administered IV vitamin D? I remember there were case studies that looked into IV vitamin D as treatment for people with severe COVID.
Got habitualized taking D since I was an early teen. My mother had a doctor who must have had a clue and told her to take it so she got me taking it. Cant say for certain it made any difference, but its now over 3 decades since and in that time I've been truly ill a handful of times, last being well over 10 yrs ago. Probably helps that I only had one childhood vaccine as well and never fell for the food pyramid lies
You mention vitamin K2 with the vitamin D but you don’t mention magnesium which is vital for it to be metabolized and most people are deficient in Mag.
Went down the vitamin D rabbit hole at the beginning of the pandemic. Read an interesting paper, how vitamin D actually drove genetic mutations. As people pushed north into Europe, skin became lighter to absorb vitamin D, but in addition, in the ages before everything was supplemented with vitamins, being dark skinned in Europe would actually cause the deaths of those people and their offspring. Nature selected for the lightest skin.
There was a couple who’s child was born extremely vitamin D deficient, and broke a lot of bones during the birthing process. The baby died, and the parents were charged with the murder because if the amount of broken bones in the child.
Eventually a doctor figured out the mother was severely vitamin D deficient, and so was the baby, which led to the issues. They were exonerated eventually.
Brilliant article, thank you! Is there a particular Vitamin D supplement you would recommend and where will i find out how much my family including 2 young kids need to take based on age, weight, skin colour, as you mentioned? Thank you sir
All vitamins are made in a lab - this is HIGHLY questionable & concerning to me... (not to mention they arent regulated - not that the FDA can be trusted to "regulate" anything).
ORGANIC RAW FOOD is the only source that should be used for nutrients.
No, (all supplemental* vitamins are made in a lab/factory.
Yes, if we eat right we get and make the vitamins we need.
As a long established organic farmer of thirty years I am aware of the inside of the system. Please be aware that food labelled 'organic' is by no means free of any of the '...icides' or other nasties, especially now financial incentives are offered for farmers to register as 'organic' producers. I have even been advised by the main regulatory body to feed non 'organic' food to my cattle and sheep, within a limit, as it is 'cheaper', so why not...
The only food which is as safe as possible is produced either by oneself or someone who is personally well known and trusted. That is why I grow grass and feed myself with my own sheep, cattle and eggs from hens on that grass. I appreciate most poeple are not so fortunate, but to think the 'organic' label is a saviour is, I am afraid, misguided.
There are indeed some badly designed trials of vitamin D3 cholecalciferol for various purposes, including tying to cure people who have already developed a serious SARS-CoV-2 infection.
Part of the problem is that many doctors and researchers do not clearly understand the immune system's reliance on vitamin D based intracrine and paracrine signaling.
Numerous peer-reviewed journal articles start with sentences like the one which begins this article: "Vitamin D is an immunoregulating hormone.". This is terminologically and conceptually completely incorrect.
While "vitamin D" is often used to refer collectively to the three compounds, it is a mistake to use it to refer to any one of them except vitamin D3 cholecalciferol or perhaps the less effective plant sourced vitamin D2 ergocalciferol.
In mammals, a hormone is a blood-borne molecule whose level is controlled by one part of the body for the purpose of signaling to cells in one or more distant parts of the body, where that level (concentration) controls some aspect of the distant cells' functioning.
Vitamin D3 cholecalciferol, produced in the skin by ultraviolet B exposure which converts 7-dehydrocholesterol, or ingested in supplements (there is very little in food) is the first of the three compounds. This is not used directly by the immune system. Over days it is hydroxylated in the liver to become 25-hydroxyvitamin D (technically 25-hydroxyvitamin D3, but in many case the '3' is left off) "25(OH)D", calcifediol, also known as "calcidiol". (Very approximately 25% of ingested vitamin D3 is converted to circulating 25-hydroxyvitamin D .)
The kidneys convert some of this with a second hydroxylation to a very low level such as 0.15 ng/mL of circulating 1,25-dihydroxyvitamin D, AKA calcitriol. This acts as a hormone, affecting several aspects of calcium-phosphate-bone metabolism, including the absorption and excretion of calcium and phosphorus and the deposition or removal of calcium compounds from the bone. This affects the blood's calcium content which needs to be very tightly regulated.
This is the only hormonal function of the three vitamin D compounds.
The immune system is unaffected by this very low, stable, level of circulating, hormonal, 1,25-dihydroxyvitamin D.
Many types of immune cell rely on a good internal level of 25-hydroxyvitamin D for their intracrine (inside each cell) and paracrine (to nearby cells) signaling system. These systems have nothing to do with endocrine (hormonal) signaling.
The 25-hydroxyvitamin D these cells have in their cytosol (internal fluids, not counting the nucleus or mitochondria) depends on passive diffusion from the bloodstream, where most 25-hydroxyvitamin D is strongly bound to the vitamin D binding protein, and most of the remainder is less strongly bound to albumin proteins. The exact levels of 25-hydroxyvitamin D in immune and other cells is not, as far as I know, measurable of reliably known. Suffice to say (see the first graph (Quraishi et al., 2014) at: https://vitamindstopscovid.info/00-evi/ that we all need at least 50 ng/mL (1 part in 20 million by mass, 125 nmol/L) 25-hydroxyvitamin D in our bloodstream in order for our immune system to mount full-strength innate and adaptive immune responses against bacterial, fungal and viral pathogens. Without proper vitamin D3 supplementation, most people have only 1/10 to 1/2 of this.
In a particular circumstance, which is different for each cell type, the cell turns on its vitamin D based intracrine signaling system: both the 1-hydroxylase enzyme and the vitamin D receptor protein are produced in the cytosol. What should happen next is that the enzyme converts 25-hydroxyvitami D, which should already be present there in sufficient concentration, into 1,25-dihydroxyvitamin D. This binds to the vitamin D receptor protein very strongly (vitamin D3 and 25-hydroxyviitamin D bind to it only very weakly) and the bound complex finds its way to the nucleus where it (thousands at once, I am describing a single pair) alters the patterns of gene transcription (to messenger RNA) in powerful ways. These changes vary from one cell type to the next. They typically include upregulating the transcription of dozens or more than a hundred genes and likewise reducing the transcription of dozens or hundreds of other genes. The altered set of mRNAs in the cytosol changes the cell's protein production and so alters the cell's behaviour.
This intracrine, internal, signaling is vital to the ability of many types of immune cell to respond to the changing circumstances of each individual cell.
This cannot work properly if there is insufficient 25-hydroxyvitamin D in the bloodstream, and so in the cells. (Paracrine signaling is similar, but some of the 1,25-dihydroxyvitamin D diffuses to nearby cells where it alters their behaviour, again in ways which differ from one cell type to the next.
This ideally good (50 ng/mL) level of circulating (blood borne) 25-hydroxyvitamin D is *not* acting as a hormone. It is not signaling anything. Its just that it needs to be 50 ng/mL or more for the immune cells to work properly.
Nor is the 1,25-dihydroxyvitamin D the cells produce internally acting as a hormone. These molecules act as intracrine and paracrine agents.
A healthy vitamin D3 intake is 70 to 90 IU per day per kilogram bodyweight - for people who are not suffering from obesity. This is 5000 to 6300 IU/day for 70 kg bodyweight. This sounds like a lot, but 5000 IU a day is 0.125 mg a day = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram, ex-factory.
By reading even a handful of the most pertinent research articles on vitamin D: https://vitamindstopscovid.info/00-evi/ any person can learn that most doctors and immunologists do not understand that for the immune system to work properly, 50 ng/mL or more circulating 25-hydroxyvitamin D is required.
The COVID-19 randomized controlled trial which best illustrates the importance of good 25-hydrocyvitamin D levels for helping people who are hospitalised with severe COVID-19 is Castillo et al. 2020. (Full refs at https://vitamindstopscovid.info/00-evi/#castillo.) Although some of the good outcomes from this RCT were due to randomization happening to put more severely affected people in the placebo group, most of the improvement was due to the rapid increase (about 4 hours) in 25-hydroxyvitami D level, from a single oral dose of 0.532 mg calcifediol, which enabled these people's immune system to work very much better.
This is about half the 1 milligram calcifediol (for 70 kg BW) recommended by Prof. Wimalawansa, but the results were spectacular. ICU admissions fell from 50% to 2% and deaths from 8% to zero.
The immune system is unaffected by hormonal 1,25-hydroxyvitamin D. It does not use hormonal signalling. "Vitamin D" does not regulate the immune system. The immune system needs good supplies of 25-hydrocxyvitamin D so it can create 1,25-dihydroxyvitamin D, inside individual cells, in particular circumstances, so the cell responds properly to its particular circumstances. This has nothing to do with hormonal signaling.
Stating that "vitamin D is a hormone" or that it, or any of the three compounds "regulates" the immune responses is not only wrong, it is dangerously misleading. This is because it misleads some doctors and even researchers into thinking that by forcibly raising circulating (hormonal) 1,25-dihjydroxyvitamin D (such as by injected, IV or oral 1,25-didhyroxyvitamin D calcitriol) that the immune system will somehow work better. This is not the case - and such treatments are likely to disturb calcium balance - something every cell in the body depends on being stable and well regulated.
(Hoorah for Substack in general, and for allowing suitably detailed, and so long, comments!)
So i take 3,000 iu of Vit D, 2,000 Quercetin, and a mixture of Vit C and Zinc daily. Is this enough to remain healthy, and safe from vaxxed people i come into contact with.
The best way to stay safe from being near the jabbed is to not stress it. If you get it in your head that you are in some danger, it can and will manifest as an illness. Elevated cortisol is a killer. Literally.
Dr. Alex Vasquez has the most info about about Vitamin D and it is well worth the time to listen too and read.
Yes, off the top of my head, he has been writing about, and cataloguing Vitamin D for years.
https://healthythinking.substack.com/p/vitamin-d-goldmine-3-pdfs-7-hours
Thx, will look into it!
Anything which costs you money is someone else with their hand in your pocket, taking your hard earned money out of it. If you want to beat Covid - kill the Coronaviruses before they ever get to be Covid this way: One heaped teaspoon of salt in a mug of warm water. Cup a hand. Sniff or Snort the lot up your nose, spitting out anything which comes down into your mouth. Burning sensation, you have a virus, so do this treatment 3 times a day (or more often) until the soreness goes away for good - blow your nose out in toilet paper and flush away washing your hands afterwards. RN has been doing his simple cure for over 29 years and he never gets Covid or a cold, me too - do the math - Vaccines released under 2 years ago vs 29 years.
When you do the salt water sniffle and it feels like you are flushing your head with water, you are OK - simple.
If you don't get Covid, because you can't, because you killed the Coronavirus, then you don't need to fork out money on cures which don't work, because if they did lots of people would be saying this works. but do you hear anyone taking Vitamin D saying it does anything. No!!
The reality is that you take Vitamin D by mouth. The pill goes down into your stomach, where it is ejected as surplus to requirements in your piss or shit - you need it to pass through the blood brain barrier, but it does not, which is why you smell it in your piss or shit.
So what makes an expert these days - people who were not experts 18 months ago - they can't forecast the future, because it has not happened yet and the past of these vaccines is only 18 months or so - disaster they have proved themselves to be, unless the purpose behind them was never Covid, but extermination and the ones who survive 50% of the way towards being Androids. Part human part machine.
THANK YOU DR. SIMON. SHARED.
Nice compilation - nutritionist 2 cents - vitamin D will not improve if the person is low in magnesium or the transport Vitamin D Binding protein/ GcMAF. Study design needs to include assessment of protein adequacy in the participant's diet and their ability to absorb magnesium. Poor gut absorption of magnesium may be an underlying factor in low vitamin D levels (and/or glyphosate interference with mineral and/or CYP enzymes).
*addition, and some pathogens or conditions include over-conversion to the active 1, 25 D so a few patients may be harmed by high dose supplements while still showing low levels of 25 D -- it is being converted to 1, 25 D.
True - same applies to Zinc. I wrote a publication about it: https://www.sciencedirect.com/science/article/pii/S120197122030624X
Thank you for the explanation. You often here comments like “the studies are flawed” or “it’s bad science” but we rarely get an explanation as to why. Your insight is a treasure.
I am writing an essay on immunoprotective strategies for the elderly at the moment and had no concise reference for lay readers to understand the problems inherent with most of the vitD literature. Very happy to have found this today and even happier to see the link to Robin’s article. Robin is a citizen-scientist hero in my book—doggedly persistent to raise public health awareness on this issue art C19 prevention. If there were medals for citizen-scientists, I would nominate Robin. Also, I would like to point ppl to the work of Sunil Wimilawansa, MD on ResearchGate. Dr. Wimilawansa provides guidance for the safe use of calcifediol, over the counter via d.velop —in the context of new onset respiratory illness. This will rapidly raise D levels for those who have not previously supplemented. Very helpful in the winter for the elderly.
Of interest, have you reviewed any of the studies that administered IV vitamin D? I remember there were case studies that looked into IV vitamin D as treatment for people with severe COVID.
Got habitualized taking D since I was an early teen. My mother had a doctor who must have had a clue and told her to take it so she got me taking it. Cant say for certain it made any difference, but its now over 3 decades since and in that time I've been truly ill a handful of times, last being well over 10 yrs ago. Probably helps that I only had one childhood vaccine as well and never fell for the food pyramid lies
You mention vitamin K2 with the vitamin D but you don’t mention magnesium which is vital for it to be metabolized and most people are deficient in Mag.
Yes, Mg+ is essential for vitD metabolism.
Vitamin K2 or K7 along with magnesium to help with proper utilization of D3(not D2). I agree
Went down the vitamin D rabbit hole at the beginning of the pandemic. Read an interesting paper, how vitamin D actually drove genetic mutations. As people pushed north into Europe, skin became lighter to absorb vitamin D, but in addition, in the ages before everything was supplemented with vitamins, being dark skinned in Europe would actually cause the deaths of those people and their offspring. Nature selected for the lightest skin.
There was a couple who’s child was born extremely vitamin D deficient, and broke a lot of bones during the birthing process. The baby died, and the parents were charged with the murder because if the amount of broken bones in the child.
Eventually a doctor figured out the mother was severely vitamin D deficient, and so was the baby, which led to the issues. They were exonerated eventually.
But yeah, that’s how important vitamin D is.
Brilliant article, thank you! Is there a particular Vitamin D supplement you would recommend and where will i find out how much my family including 2 young kids need to take based on age, weight, skin colour, as you mentioned? Thank you sir
All vitamins are made in a lab - this is HIGHLY questionable & concerning to me... (not to mention they arent regulated - not that the FDA can be trusted to "regulate" anything).
ORGANIC RAW FOOD is the only source that should be used for nutrients.
http://www.shotsoftruth.com/vitamin-d-exposed-all-vitamins-are-made-in-a-lab..html
No, (all supplemental* vitamins are made in a lab/factory.
Yes, if we eat right we get and make the vitamins we need.
As a long established organic farmer of thirty years I am aware of the inside of the system. Please be aware that food labelled 'organic' is by no means free of any of the '...icides' or other nasties, especially now financial incentives are offered for farmers to register as 'organic' producers. I have even been advised by the main regulatory body to feed non 'organic' food to my cattle and sheep, within a limit, as it is 'cheaper', so why not...
The only food which is as safe as possible is produced either by oneself or someone who is personally well known and trusted. That is why I grow grass and feed myself with my own sheep, cattle and eggs from hens on that grass. I appreciate most poeple are not so fortunate, but to think the 'organic' label is a saviour is, I am afraid, misguided.
These reports consider the relationship of vitamin D levels to Covid severity. One's decision about optimal vitamin D levels should also consider other effects of vitamin D. Several studies summarized at https://www.consumerlab.com/reviews/vitamin-d-supplements-review/vitamin-d/#howmuch imply that 50 ng/mL is probably too high.
There are indeed some badly designed trials of vitamin D3 cholecalciferol for various purposes, including tying to cure people who have already developed a serious SARS-CoV-2 infection.
Part of the problem is that many doctors and researchers do not clearly understand the immune system's reliance on vitamin D based intracrine and paracrine signaling.
Numerous peer-reviewed journal articles start with sentences like the one which begins this article: "Vitamin D is an immunoregulating hormone.". This is terminologically and conceptually completely incorrect.
While "vitamin D" is often used to refer collectively to the three compounds, it is a mistake to use it to refer to any one of them except vitamin D3 cholecalciferol or perhaps the less effective plant sourced vitamin D2 ergocalciferol.
Long-time (1975 to the present) vitamin D researcher Reinhold Vieth wrote about this in 2004: "Why 'Vitamin D' is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids" Reinhold Vieth, J. Steroid Biochemistry and Molecular Biology 2004-06-30 https://sci-hub.se/10.1016/j.jsbmb.2004.03.037 . I wrote about this in 2020: https://vitamindstopscovid.info/02-intracrine/#02-nothorm and in 2022: https://vitamindstopscovid.info/00-evi/#02-compounds .
In mammals, a hormone is a blood-borne molecule whose level is controlled by one part of the body for the purpose of signaling to cells in one or more distant parts of the body, where that level (concentration) controls some aspect of the distant cells' functioning.
Vitamin D3 cholecalciferol, produced in the skin by ultraviolet B exposure which converts 7-dehydrocholesterol, or ingested in supplements (there is very little in food) is the first of the three compounds. This is not used directly by the immune system. Over days it is hydroxylated in the liver to become 25-hydroxyvitamin D (technically 25-hydroxyvitamin D3, but in many case the '3' is left off) "25(OH)D", calcifediol, also known as "calcidiol". (Very approximately 25% of ingested vitamin D3 is converted to circulating 25-hydroxyvitamin D .)
The kidneys convert some of this with a second hydroxylation to a very low level such as 0.15 ng/mL of circulating 1,25-dihydroxyvitamin D, AKA calcitriol. This acts as a hormone, affecting several aspects of calcium-phosphate-bone metabolism, including the absorption and excretion of calcium and phosphorus and the deposition or removal of calcium compounds from the bone. This affects the blood's calcium content which needs to be very tightly regulated.
This is the only hormonal function of the three vitamin D compounds.
The immune system is unaffected by this very low, stable, level of circulating, hormonal, 1,25-dihydroxyvitamin D.
Many types of immune cell rely on a good internal level of 25-hydroxyvitamin D for their intracrine (inside each cell) and paracrine (to nearby cells) signaling system. These systems have nothing to do with endocrine (hormonal) signaling.
The 25-hydroxyvitamin D these cells have in their cytosol (internal fluids, not counting the nucleus or mitochondria) depends on passive diffusion from the bloodstream, where most 25-hydroxyvitamin D is strongly bound to the vitamin D binding protein, and most of the remainder is less strongly bound to albumin proteins. The exact levels of 25-hydroxyvitamin D in immune and other cells is not, as far as I know, measurable of reliably known. Suffice to say (see the first graph (Quraishi et al., 2014) at: https://vitamindstopscovid.info/00-evi/ that we all need at least 50 ng/mL (1 part in 20 million by mass, 125 nmol/L) 25-hydroxyvitamin D in our bloodstream in order for our immune system to mount full-strength innate and adaptive immune responses against bacterial, fungal and viral pathogens. Without proper vitamin D3 supplementation, most people have only 1/10 to 1/2 of this.
In a particular circumstance, which is different for each cell type, the cell turns on its vitamin D based intracrine signaling system: both the 1-hydroxylase enzyme and the vitamin D receptor protein are produced in the cytosol. What should happen next is that the enzyme converts 25-hydroxyvitami D, which should already be present there in sufficient concentration, into 1,25-dihydroxyvitamin D. This binds to the vitamin D receptor protein very strongly (vitamin D3 and 25-hydroxyviitamin D bind to it only very weakly) and the bound complex finds its way to the nucleus where it (thousands at once, I am describing a single pair) alters the patterns of gene transcription (to messenger RNA) in powerful ways. These changes vary from one cell type to the next. They typically include upregulating the transcription of dozens or more than a hundred genes and likewise reducing the transcription of dozens or hundreds of other genes. The altered set of mRNAs in the cytosol changes the cell's protein production and so alters the cell's behaviour.
This intracrine, internal, signaling is vital to the ability of many types of immune cell to respond to the changing circumstances of each individual cell.
This cannot work properly if there is insufficient 25-hydroxyvitamin D in the bloodstream, and so in the cells. (Paracrine signaling is similar, but some of the 1,25-dihydroxyvitamin D diffuses to nearby cells where it alters their behaviour, again in ways which differ from one cell type to the next.
This ideally good (50 ng/mL) level of circulating (blood borne) 25-hydroxyvitamin D is *not* acting as a hormone. It is not signaling anything. Its just that it needs to be 50 ng/mL or more for the immune cells to work properly.
Nor is the 1,25-dihydroxyvitamin D the cells produce internally acting as a hormone. These molecules act as intracrine and paracrine agents.
A healthy vitamin D3 intake is 70 to 90 IU per day per kilogram bodyweight - for people who are not suffering from obesity. This is 5000 to 6300 IU/day for 70 kg bodyweight. This sounds like a lot, but 5000 IU a day is 0.125 mg a day = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram, ex-factory.
By reading even a handful of the most pertinent research articles on vitamin D: https://vitamindstopscovid.info/00-evi/ any person can learn that most doctors and immunologists do not understand that for the immune system to work properly, 50 ng/mL or more circulating 25-hydroxyvitamin D is required.
Vitamin D3 supplemental intake quantities as ratios of body weight, according to health status: : https://vitamindstopscovid.info/00-evi/index.html#sjw-updated-ratios .from Professor Sunil Wimalawansa's recent article in Nutrients: "Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19: https://www.mdpi.com/2072-6643/14/14/2997/htm . To boost levels in 4 hours one needs about 1 milligram of calcifediol, which _is_ 25-hydroxyvitamin D and goes straight into circulation. Bolus vitamin D3 takes about 4 hours due to the need of hydroxylation in the liver: https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin .
The COVID-19 randomized controlled trial which best illustrates the importance of good 25-hydrocyvitamin D levels for helping people who are hospitalised with severe COVID-19 is Castillo et al. 2020. (Full refs at https://vitamindstopscovid.info/00-evi/#castillo.) Although some of the good outcomes from this RCT were due to randomization happening to put more severely affected people in the placebo group, most of the improvement was due to the rapid increase (about 4 hours) in 25-hydroxyvitami D level, from a single oral dose of 0.532 mg calcifediol, which enabled these people's immune system to work very much better.
This is about half the 1 milligram calcifediol (for 70 kg BW) recommended by Prof. Wimalawansa, but the results were spectacular. ICU admissions fell from 50% to 2% and deaths from 8% to zero.
The immune system is unaffected by hormonal 1,25-hydroxyvitamin D. It does not use hormonal signalling. "Vitamin D" does not regulate the immune system. The immune system needs good supplies of 25-hydrocxyvitamin D so it can create 1,25-dihydroxyvitamin D, inside individual cells, in particular circumstances, so the cell responds properly to its particular circumstances. This has nothing to do with hormonal signaling.
Stating that "vitamin D is a hormone" or that it, or any of the three compounds "regulates" the immune responses is not only wrong, it is dangerously misleading. This is because it misleads some doctors and even researchers into thinking that by forcibly raising circulating (hormonal) 1,25-dihjydroxyvitamin D (such as by injected, IV or oral 1,25-didhyroxyvitamin D calcitriol) that the immune system will somehow work better. This is not the case - and such treatments are likely to disturb calcium balance - something every cell in the body depends on being stable and well regulated.
(Hoorah for Substack in general, and for allowing suitably detailed, and so long, comments!)
So i take 3,000 iu of Vit D, 2,000 Quercetin, and a mixture of Vit C and Zinc daily. Is this enough to remain healthy, and safe from vaxxed people i come into contact with.
The best way to stay safe from being near the jabbed is to not stress it. If you get it in your head that you are in some danger, it can and will manifest as an illness. Elevated cortisol is a killer. Literally.
Agreed