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D is powerful for sure. Are you familiar with the research on how many forms supplementation can lead to a false signal as D needs to be sulfated by Sunlight?

https://romanshapoval.substack.com/p/why-vitamin-d-supplements-dont-work

It's my understanding that if ingesting D as a supplement, it's absorbed optimally when there is the right balance of A and K2, as in fermented cod liver oil.

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Jul 12, 2023Liked by Dr. Simon

Hello Dr. Simon 😊 Absolutely ! I couldn't agree with you more. I am grateful for your experienced, eminent knowledge and insightful research.

I am sorry for this first post, but I would like to present my humble research in a different field than yours, so thank you very much.

Those in power are making the word "LGBTQIA" popular all over the world and spurring depopulation. And the latest research become evident that transgender people actually have a lot of stress, and they have been shown to be very strong suicidal ideation. See (2023 May; 38(6): 1357-1365.):

Suicidal Ideation Disparities Among Transgender and Gender Diverse Compared to Cisgender Community Health Patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844943/

LGBT people are "the cause" of this high suicidal ideation because of the high levels of certain stress hormones. That stress hormone is estrogen. (Estrogen, which is also called an "environmental hormone," is produced in the body as a stress hormone even in men, so it is by no means a "female hormone," by the way.)

Studies get published that young teenage women taking the contraceptive pill increase their risk of developing depression.

Population-based cohort study of oral contraceptive use and risk of depression

https://research.regionh.dk/da/publications/population-based-cohort-study-of-oral-contraceptive-use-and-risk-

The contraceptive pill is main components of artificial synthetic products called estrogen and progestin, which have the opposite effect of natural progesterone.

In younger women, even if they stop taking the contraceptive pill, the risk of developing depression increases.

The study that the contraceptive pill is the writes exactly the opposite of the fact that the contraceptive pill does increase the risk of depression in adult women, or reduces the risk of ovarian or uterine cancer, but this would be "proneur" to those in power. Because Estrogen acts on both the sideration and grow bigger of breast cancer.

Estrogen a more powerful breast cancer culprit than we realized

https://news.harvard.edu/gazette/story/2023/05/estrogen-a-more-powerful-breast-cancer-culprit-than-we-realized/

Modern society even just living a normal life is exposed to estrogen agents to the point of excess estrogen.

This might not sound like the truth, but honestly consuming large amounts of omega-3 (fish oil) can slow down the glyco-energy metabolism, causing strong suicidal ideation, or in some people murder ideation. This is because DHA, especially in fish oil, among PUFAs, increases the production of estrogen in the brain.

Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid

https://www.nature.com/articles/s41598-017-06630-0

When you are attacked by the feeling that you want to disappear from this world, you can say, "you are under intense stress and hacked by stress hormones such as estrogen."

Additionally, it has been pointed out that estrogen doesn’t improve memory, but rather has the effect of put off memory. This is because estrogen blocks the glyco-energy metabolism in brain neurons and blocks whole-brain functional connectivity.

Impact of exogenous estradiol on task-based and resting-state neural signature during and after fear extinction in healthy women

https://www.nature.com/articles/s41386-021-01158-4

It was found that a large and current epidemiological study in Denmark found that even short-term estrogen administration to women aged 55 and younger was correlation with an increased risk of dementia. Incidentally, the correlation with the increased risk of dementia due to long-term estrogen administration has been observed as in previous studies.

Menopausal hormone therapy and dementia: nationwide, nested case-control study

https://www.bmj.com/content/381/bmj-2022-072770

In this menopausal hormone therapy for women, a compound drug is prescribed "Estrogen + progestin". However, research results have shown that there is no association between progestin monotherapy and an increased risk of dementia. This means that estrogen in hormone therapy for menopause is associated with an increased risk of developing dementia. In animal experiments, it has already been reported that dysmnesia no longer occurs by blocking estrogen synthesis.

Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats

https://www.sciencedirect.com/science/article/abs/pii/S0039128X14002037

As long as modern people don't know the basic principle of "glyco-energy metabolism", the probability of developing premature senility is high, even if they can avoid the development of cancer and cardiovascular and cerebrovascular disorders due to excess estrogen.

From the above, "glyco-energy metabolism" is extremely important for us to maintain our health. As such, organic honey with a high fructose content that has passed official tests (drugs, fructose syrup (fructose-glucose corn syrup), pesticides, glyphosate, heavy metal contamination) is introduced below. If you prefer, please refer to it. 😊

https://www.goodmates.sg/products/honey-for-life-red-gum-ta-40

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Simon,

I have more than a few time pointed out to you that your Vit D3 product literally contain the main ingredient to rat poison. You have, instead of looking in to it, opted to block me on twitter.

There are literally hundreds of sources on the internet circulating that point this out. Here is just a few sources:

- https://www.youtube.com/watch?v=d66ZRyvrQEI

- https://www.youtube.com/watch?v=AMv0tB_luQ0

- https://jimstephensonjr.substack.com/

- https://www.bitchute.com/video/r8q2SfsBCGYy/

All you need to do is google "cholecalciferol rat poison"

Cholecalciferol is a form of Vitamin D3 which is used to poison animals by raising calcium levels in the blood to induce a heart attack. Its use as a poison is relatively new. It was developed in the 1980s in the USA to kill rats and mice and was introduced in New Zealand in 1995 for possum control.

This is the OSHA safety data for D3. It is considered a poison. https://twitter.com/Usul2020/status/1700571692379046022?s=20

For the love of all things good in this world, stop promoting this to people!

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The diagram depicts, on the lower left, 1,25-dihydroxyvitamin, AKA calcitriol, the molecule which activates the "vitamin D receptor" (VDR) which, when activated causes the cell to change its behaviour via altering the rates of transcription of dozens or hundreds of genes, in a way which varies from one cell type to the next. This is widely referred to as "activated vitamin D". However, it would be better to think of the VDR as the "calcitriol receptor", since its rate of activation by vitamin D3 cholecalciferol and 25-hydroxyvitamin D calcifediol (sometimes also known as calcidiol) is much lower.

Calcitriol is a signaling molecule, while vitamin D3 and 25-hydroxyvitamin D (made primarily in the liver by adding an oxygen-hydrogen group to the 25th carbon) are not. Calcitriol is best known as a hormone, made in the kidneys (as indicated by the diagram) in very limited amounts, to attain a level in the bloodstream around 0.05 to 0.1 ng/mL, with that level being used by the kidneys (as part of a feedback network with the parathyroid gland and osteocyte cells in bone) to regulate calcium-phosphate-bone metabolism.

Hormonal signaling involves some part of the body controlling the level (concentration) of a molecule in the bloodstream and in some cases so the the cerebrospinal fluid (in which the brain and spinal cord are bathed) for the purpose of that level being sensed by one or more cell types, with those cells, anywhere in the body, changing their behaviour according to the level they detect.

All medical professionals understand this. However, what the diagram doesn't show and what most medical professionals don't understand is that the immune system does not work with this calcitriol hormonal signaling system at all. Many types of immune cells - and other cell-types which are not involved in calcium-phosphate-bone metabolism - hydroxylate 25-hydroxyvitamin D, on the number 1 carbon, to become calcitriol, inside the cell, only when a specific, cell-type dependent, condition occurs. That calcitriol functions not as a hormone, but as an intracrine signaling agent (to alter the behaviour of that cell) or as a paracrine signaling agent (by diffusing to nearby cells, probably of different types, and altering their behaviour). This calcitriol is at a much higher level, ca. 1 ng/mL, than the very low level of hormonal calcitriol in the whole body, so these signaling systems are not significantly affected by that hormonal calcitriol.

Without this understanding, many medical professionals assume, wrongly, that the immune system depends on the very low level of circulating, hormonal, calcitriol. This is why Simon and I began our article https://brownstone.org/articles/vitamin-d-everything-you-need-to-know/ with an explanation of 25-hydroxyvitamin D based intracrine and paracrine signaling. Without proper supplies of 25-hydroxyvitamin D, these systems cannot function properly. Most people don't have enough 25-hydroxyvitamin D for their immune systems to work properly.

There is very little vitamin D3 in food. There is enough in food to help towards attaining the 15 to 20 ng/mL circulating 25-hydroxyvitamin D the kidneys need to function properly. The kidney cells bring 25-hydroxyvitamin D across their cell membrane and into their cytosol with an actively powered transporter system which works with the vitamin D binding protein, to which most 25-hydroxyvitamin D molecules in circulation are bound.

Immune cells - and as far as I know, all other cell types which rely use 25-hydroxyvitamin D for intracrine and/or paracrine signaling) have no such active transport. They rely on diffusion across their cell membranes from the small fraction of the circulating 25-hydroxyvitamin D which is not bound strongly to the vitamin D binding protein, or, more weakly to albumin proteins. This means that immune cells can only respond to their changing circumstances rapidly and fully when there is about 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) 25-hydroxyvitamin D in the bloodstream.

There is no way of even approaching this level from the very small amounts of vitamin D3 in food. It is possible to attain 50 ng/mL or somewhat more circulating 25-hydroxyvitamin D from UV-B skin exposure. However, this does not work very well (and so would require massive exposure) on brown or black skin - and all such UV-B exposure causes DNA damage and so raises the risks of skin cancer.

There are multiple healthy aspects of being outdoors, and being exposed to the Sun. However, to try to attain 50 ng/mL or more circulating 25-hydroxyvitamin D via limited vitamin D3 in food, with the need for high levels of UV-B exposure all year round, would be impractical for most people living far from the equator (and impossible during monsoon season) and unhealthy due to the increased risk of skin cancer.

The only practical and safe way of attaining 25-hydroxyvitamin D levels of 50 ng/mL or more is vitamin D3 supplementation. Fortunately, the quantities involved a minuscule - such as, for 70 kg body weight without obesity, 1 gram every 22 years. This is 1/8000th of a gram per day, on average. Unfortunately, this is also known by the scarily high number of "5000 International Units", which tends to put people off - especially if they believe, wrongly, that "vitamin D is a hormone".

Our article gives some body-weight ratio based guidance on how much vitamin D3 to take for most people to attain at least 50 ng/mL circulating 25-hydroxyvitamin D, without the need for blood tests and medical monitoring.

The magnesium article: Cazzola et al. 2020 "Going to the roots of reduced magnesium dietary intake: A tradeoff between climate changes and sources" https://www.cell.com/heliyon/fulltext/S2405-8440(20)32233-7 looks interesting.

Is it really necessary to have 100 mg magnesium per 0.025 mg (1000 IU) of vitamin D3?

Here are three articles on vitamin K2: https://doi.org/10.1155/2017/6254836 , https://doi.org/10.1155/2018/4629383 and https://doi.org/10.3390/ijms20040896 - I have only read the first one so far.

Zinc and omega 3 fatty acids are also very important.

My website https://5nn.info links to other sites on which I have nutrition information. This is easy to remember - and it stands for "5 neglected nutrients". These are vitamin D3, magnesium, boron, omega 3 fatty acids and zinc.

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What are your thoughts on boron? Lots of talk about VitD, K2, and Mg...but I rarely hear anyone mention boron in the mix.

https://open.substack.com/pub/conspiracysarah/p/boron-the-little-trace-mineral-that?r=thuli&utm_medium=ios&utm_campaign=post

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Sep 8, 2023·edited Sep 8, 2023

Dr. Göddeck, can you please share the best forms of magnesium and zinc to take? There are so many of each and it gets confusing…

Thank you in advance for your reply. God bless!

Barbara

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